Treatment for HoFH
Homozygous familial hypercholesterolemia (HoFH) is treatable. In fact, there are multiple effective treatments for HoFH available today. A combination of treatments is usually required to lower LDL-cholesterol (bad cholesterol).
Many of the same treatments used to treat Familial Hypercholesterolemia can be used to treat HoFH.
Often, HoFH patients will require even more intensive therapy to bring their LDL cholesterol ("bad cholesterol") levels down.
- LDL Apheresis - LDL apheresis (also called lipoprotein apheresis, LA) can be performed on HoFH patients as well as more serious HeFH patients. This procedure involves blood cleansing every other week (or sometimes weekly) with a special machine that looks like a dialysis machine. The procedure takes between one and a half to three hours, and typically drops LDL levels by 70%. Unfortunately, LDL rises over time and, for this reason, repeat treatments are necessary. About 60 lipoprotein apheresis centers exist in the US. To locate a center near you, click here.
- Lomitapide (marketed as Juxtapid in the U.S.) - Lomitapide works in the liver by partially blocking the production of LDL particles. It is approved as an adjunct to a low-fat diet and other lipid lowering treatments. It is an oral capsule.
Clinical Trials for HoFH Treatments
Additional therapies are in clinical trials and development. If you are interested in learning about a clinical trial in your area, visit our clinical trials page.